Study Shorts 1 * Coffee Antivirals * Aspirin In Preeclampsia * Ginkgo Biloba – Neuroinflammation * Allopregnanolone – Alzheimer’s * Hypothyroidism – Hypogonadism

Caffeic acid, a coffee-related organic acid, inhibits infection by severe fever with thrombocytopenia syndrome virus in vitro

Caffeic acid, an organic acid found in coffee, inhibits (SFTSV) viral replication in cell culture.

“CA (caffeic acid) acted on (Severe fever with thrombocytopenia syndrome  virus) and inhibited viral infection and spread, mainly by inhibiting the binding of SFTSV to the cells. We therefore demonstrated CA to be a potential anti-SFTSV drug for preventing and treating SFTS.”

Low-dose aspirin at ≤16 weeks of gestation for preventing preeclampsia and its maternal and neonatal adverse outcomes: A systematic review and meta-analysis

A meta-analysis of 10 random control trials finds that 50-150mg aspirin per day reduces relative risk of preeclampsia by one third. Low dose aspirin is associated with lower risk of stillbirth and it is also associated with increased newborn weight.

“The meta‑analysis demonstrated that, compared with placebo or no treatment, low‑dose aspirin was associated with a significant reduction in the overall risk ratio (RR) of preeclampsia regardless of the time to delivery [RR=0.67; 95% confidence interval (CI)=0.57‑0.80]. This was apparent for preterm preeclampsia (RR=0.35; 95% CI=0.13‑0.94) but not for term preeclampsia (RR=1.01; 95% CI=0.60‑1.70). Except for postpartum hemorrhage, low‑dose aspirin also significantly reduced the risk of maternal and neonatal adverse outcomes. In conclusion, low‑dose aspirin in women at risk of preeclampsia, commenced at ≤16 weeks of gestation, was associated with a reduced risk of preterm preeclampsia, and of adverse maternal and neonatal outcomes.”

Anti-neuroinflammatory effects of Ginkgo biloba extract EGb761 in LPS-activated primary microglial cells

Ginkgo biloba extract EGb 761 lowers inflammatory cytokine release by bacterial endotoxin (LPS) in rat microglia. These cells, found in the brain and spinal cord, are thought to contribute to inflammation related to Alzheimer’s and other types of dementia. The effect seems to be by inhibiting the release of prostaglandin E2.

“Ginkgo biloba extract EGb 761 displayed anti-neuroinflammatory activity in LPS-activated primary microglia cells. EGb 761 was able to reduce neuroinflammatory activation by targeting the COX/PGE2 pathway. This effect might contribute to the established clinical cognitive efficacy in Alzheimer’s disease, vascular and mixed dementia.”

Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer’s disease

Allopregnanolone could repair cognitive deficits in Alzheimer’s, based on animal model. Allopregnanolone is a metabolite of progesterone and elevated with pregnenolone.

APα (allopregnanolone) reversed the cognitive deficits to restore learning and memory performance to the level of normal non-Tg mice. In 3xTgAD mice, APα-induced survival of neural progenitors was significantly correlated with APα-induced memory performance. These findings suggest that early neurogenic deficits, which were evident before immunodetectable Aβ, may contribute to the cognitive phenotype of AD, and that APα (allopregnanolone)could serve as a regenerative therapeutic to prevent or delay neurogenic and cognitive deficits associated with mild cognitive impairment and Alzheimer’s disease.

MP74-19 EFFECTS OF HYPOTHYROIDISM ON LOWER URINARY TRACT SYMPTOMS, TESTOSTERONE AND SEXUAL FUNCTION IN MEN

Hypothyroidism (TSH>4.0) is associated with lower testosterone, sexual function and larger prostate. Hypogonadism was doubled in hypothyroid men.

…serum testosterone, IIEF sexual desire scores and IIEF overall satisfaction scores were negatively associated with the hypothyroidism, while prostate volumes was positively associated with the hypothyroidism. … Prevalence of hypogonadism was 13.8% in patients with hypothyroidism vs 6.5% in normal thyroid function group.

Serum testosterone level and sexual desire were decreased in male hypothyroidism patients. Therefore, it is important to identify and treat hypothyroidism when treating hypogonadism in clinical practice.

 

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