* Opioids – Fertility & Hormones * B1/Thiamine – Alcohol & Dementia * Sterilized Probiotics – Obesity & Diabetes * Deep Sleep – Androgens *

Tramadol (opioid) abuse is associated with a dose‐ and time‐dependent poor sperm quality and hyperprolactinaemia in young men

Tramadol is a common opioid painkiller. Previous studies have shown negative reproductive effects in male animals. This study found low testosterone, high prolactin, and poor sperm parameters associated with tramadol abuse. Prolactin was doubled in the tramadol group. Total testosterone was 2.0 for abusers, vs 5.8 in non users. Some factors, like smoking, were controlled for in the study, others, like acetaminophen use, were not. See risks of acetaminophen (*), and benefits of aspirin (*)

“We aimed to investigate tramadol impact on sperm quality and on levels of testosterone, prolactin and gonadotropins, in tramadol abusers (n = 30) to age‐matched control (n = 30)…
Tramadol abuse is associated with poor sperm quality, hyperprolactinaemia and hypergonadotropic hypogonadism. We recommend semen analysis for tramadol long‐intakes, question sperm donors and follow‐up studies to prevent and reverse tramadol‐induced testicular damage.

Thiamine for preventing dementia development among patients with alcohol use disorder: A nationwide population-based cohort study

This study looked at the effect of vitamin B1/Thiamine supplementation on the risk of dementia in alcoholism. Alcohol depletes vitamin B1. The analysis found that people receiving B1 supplements had half the risk of dementia at the end of the five year period.

“We retrieved data for this retrospective cohort study from the Longitudinal Health Insurance Database 1995–2000. Patients receiving thiamine therapy after the diagnosis of alcohol use disorder were recruited as the thiamine therapy (TT) group, and the comparison group without TT (NTT group) included randomly assigned and age-, sex-, and index year-matched individuals with alcohol use disorder. Demographic data, comorbid medical disorders, and psychotropic medication use were evaluated and controlled. The cumulative defined daily dose (DDD) was analyzed to demonstrate the dose effect…
The results indicated that thiamine therapy could be a protective factor for dementia development in patients with alcohol use disorder. Thiamine therapy should be a crucial part of the treatment plan and health policies to prevent dementia development or progression among patients with alcohol use disorder.

Sterilized bifidobacteria suppressed fat accumulation and blood glucose level

Seven-week-old male mice acclimatised on a normal lab diet for one week. Then the animals were split into three groups. All animals in experimental groups were fed a high-fat diet designed to make the animals obese and diabetic. Two groups got different doses of sterilized bifidobacteria with the high-fat diet. After four weeks the mice which were given sterilized bifidobacteria had lower body fat, triglycerides, total cholesterol and blood glucose than the animals on the high-fat diet without bifidobacteria supplementation. The supplement led to decreased levels of endotoxin in the blood. Still, the animals which were not on a high-fat diet were healthier than those on the high-fat diet+bifidobacteria. The study shows therapeutic effects from non-viable bacteria. More on endotoxin, bifido, boesity and diabetes here (*) and here(*).

The aim of this study was to elucidate the roles of sterilized bifidobacteria in obesity and lipid metabolism. To this end, mice were orally ingested sterilized bacteria. Male C57BL/6J mice aged 7 wks were raised on a high-fat diet and received oral sterilized bifidobacteria for 4 wks. Although the amount of food they ingested did not change in response to bifidobacteria administration, both weight gain and epididymal body fat mass were significantly reduced. In addition, the elevated blood glucose, triglyceride, and total cholesterol levels observed in the mice on the high-fat diet all decreased in response to bifidobacteria treatment. Hepatic triglyceride levels also decreased. Furthermore, oral glucose tolerance and insulin resistance tests indicated that sterilized bifidobacteria improved glucose tolerance and diminished insulin resistance. Sterilized bifidobacteria also decreased blood lipopolysaccharides and altered intestinal flora. The present study indicates that in mice on a high-fat diet, sterilized bifidobacteria suppressed fat accumulation, improved insulin resistance, and lowered blood glucose levels.”

Slow-wave sleep and androgens: selective slow-wave sleep suppression affects testosterone and 17α-hydroxyprogesterone secretion

This study examined the effect of slow wave sleep suppression on hormones. Slow wave sleep is also called deep sleep, and it is critical for many restorative functions. The study reduced time spent in slow wave sleep using a noise machine. The alterations in sleep patterns led to decreases in testosterone and 17-OHP.

“(Slow wave sleep) SWS suppression reduced overall SWS duration by 54.2% without significant changes in total sleep time and sleep efficiency. In the session with selective SWS suppression, the average level of morning testosterone was lower than in the control session (p = .017). Likewise, 17-OHP was lower in the SWS suppression condition (p = .011) whereas the ratio of DHEA/Ad was higher (p = .025). There were no significant differences between sessions in cortisol, Ad, or DHEA concentrations.

The effect of selective SWS suppression on morning levels of testosterone and 17-OHP points to the importance of SWS for the synthesis and secretion of androgens. These results suggest that chronic sleep problems, which lead to reduced SWS, increase the risk for the development of androgen deficiency in the long term.”