Glycine, Sleep, And Muscle

Glycine Improves Sleep And Increases Muscle Mass Glycine is an amino acid that makes up a large part of gelatin/collagen. Amino acids are generally categorized as essential or non-essential. Essential amino acids are those which cannot be made from other materials within the body, but which there is a biological requirement for. Glycine can be […]

SS6 * Light – Diabetic Neuropathy * BPA – Neonatal Heart * Gelatin – Neuromuscular Metabolism * Neonicotinoids – Estrogen * Trichotillomania – Progesterone

Photobiomodulation induces antinociception, recovers structural aspects and regulates mitochondrial homeostasis in peripheral nerve of diabetic mice Red light therapy improves pain and nerve function in an animal model of Diabetic Peripheral Neuropathy. Scientists prove the usefulness of a pretty simple light therapy protocol using non-pulsed light, this is a relatively simple protocol to replicate. You can […]

Glycine and longevity

Caloric Restriction, Amino Acids, And Longevity

The effect of caloric restriction on longevity in animals has been observed as far back as 1935 when McCay observed extended lifespan in underfed rats. In that experiment, the rodents were weighed weekly and those on the restricted diet received calories based on weekly weight gain, they were allowed to gain 10g per week. The […]

Study Shorts 4 * NO – Cellular Respiration * Chamomile – NO * Taurine – MELAS * Aspirin – Thromboembolism * Skin Bacteria – Cancer *

Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase Nitric oxide inhibits cellular respiration, “one of the key ways a cell releases chemical energy to fuel cellular activity”, by competing with oxygen. This may be one of the main reasons the nitric oxide can have detrimental effects.  “Nitric oxide (NO) reversibly inhibits […]

Phage Therapy Guide

Introduction To Phage Therapy

Bacteriophages are viruses which are found naturally in the environment. They use bacterial cells to replicate, destroying the bacteria in the process. “Phages” provide an alternative to antibiotics and they may be the solution to antibiotic resistance. This article gives a brief overview of the history of phage therapy, their mechanism of action, risk and […]

Study Shorts 3 * IBS – Bifido * Osteoarthritis – Bifido * Iron – Huntington’s * High-Fat – Compulsive Eating * Chronic Stress – Serotonin *

Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients Searching for biomarkers for irritable bowel syndrome, researchers found (supernatant) fluid from IBS patients expressed different enzymes that break down protein (protease). Elevated elastase in IBS potentates serotonin and histamine. A protease […]

Chronic Fatigue And The Gut – On Patreon

In the previous two articles on chronic fatigue I looked at the effect of alterations in thyroid hormones and pyruvate dehydrogenase. Here, I’m going to look at some of the effects of gastrointestinal dysfunction on both of these processes and their relationship to chronic fatigue.


Thiamine (B1) And Chronic Fatigue

In part II of this series I shift focus from thyroid to thiamine, looking at the effect of vitamin B1 on pyruvate dehydrogenase and the connection to chronic fatigue syndrome(s). Part 1 is here Thyroid And Chronic Fatigue Many associations have been made with chronic fatigue syndrome and the related condition fibromyalgia, both symptomatic and biochemical. […]

Chronic Fatigue Thyroid

Thyroid And Chronic Fatigue

A recent article on the effect of thyroid function in chronic fatigue piqued my interest in the subject. The study showed that some people with chronic fatigue syndrome were suffering from what I would call a functional thyroid deficiency. Generally, low thyroid, or hypothyroidism, is clinically determined by the levels of thyroid stimulating hormone (TSH). […]